β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.

@article{Drr2010blockerTA,
  title={β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.},
  author={Marcus D{\"o}rr and Carsten Oliver Schmidt and Thomas Spielhagen and Alexa Bornhorst and Katharina Hentschel and Christina Franz and Klaus Empen and Thomas Kocher and Scott R. Diehl and Heyo Klaus Kroemer and Henry V{\"o}lzke and Ralf Ewert and Stephan B. Felix and Dieter Rosskopf},
  journal={Pharmacogenomics},
  year={2010},
  volume={11 9},
  pages={1209-21}
}
AIM Impaired heart rate (HR) response to exercise is associated with increased cardiovascular morbidity and mortality. We analyzed whether common variants (rs5443/C825T and rs5442/G814A) in the G-protein β3 subunit (GNB3) gene modulate interindividual variation in β-blocker responses with respect to HR. MATERIALS & METHODS Among 1614 subjects (347 current β-blocker users) of a population-based study, HR during symptom-limited exercise testing was analyzed by multilevel linear regression… CONTINUE READING