β-arrestin promotes c-Jun N-terminal kinase mediated apoptosis via a GABA(B)R·β-arrestin·JNK signaling module.

@article{Wu2014arrestinPC,
  title={β-arrestin promotes c-Jun N-terminal kinase mediated apoptosis via a GABA(B)R·β-arrestin·JNK signaling module.},
  author={Jin-xia Wu and Feng-Xiao Shan and Jun-nian Zheng and Dong-sheng Pei},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2014},
  volume={15 2},
  pages={
          1041-6
        }
}
Evidence is growing that the GABAB receptor, which belongs to the G protein-coupled receptor (GPCR) superfamily, is involved in tumorigenesis. Recent studies have shown that β-arrestin can serve as a scaffold to recruit signaling protein c-Jun N-terminal knase (JNK) to GPCR. Here we investigated whether β-arrestin recruits JNK to the GABAB receptor and facilitates its activation to affect the growth of cancer cells. Our results showed that β-arrestin expression is decreased in breast cancer… CONTINUE READING

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