β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Abstract

β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation of the β-arrestin-2 gene, barr2, in β-cells of adult mice greatly impairs insulin release and glucose tolerance in mice fed with a calorie-rich diet… (More)
DOI: 10.1038/ncomms14295

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@inproceedings{Zhu2017arrestin2IA, title={β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions}, author={Lu Zhu and Joana Almaça and Prasanna Keerthi Dadi and Hao Hong and Wataru Sakamoto and Mario Rossi and Regina Lee and Nicholas C Vierra and Huiyan Lu and Yinghong Cui and Sara M. McMillin and Nicole A. Perry and Vsevolod V. Gurevich and Amy Huei-Yi Lee and Bryan Kuo and Richard D. Leapman and Franz M. Matschinsky and Nicolai M. Doliba and Nikhil M Urs and Marc G. Caron and David A Jacobson and Alejandro Caicedo and Juergen Wess}, booktitle={Nature communications}, year={2017} }