β-adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with VEGF signalling

@article{Sharifpanah2014adrenergicRA,
  title={β-adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with VEGF signalling},
  author={Fatemeh Sharifpanah and Fatjon Saliu and Mohamed M. Bekhite and Maria Wartenberg and Heinrich Sauer},
  journal={Cell and Tissue Research},
  year={2014},
  volume={358},
  pages={443-452}
}
The β-adrenoceptor antagonist Propranolol has been successfully used to treat infantile hemangioma. However, its mechanism of action is so far unknown. The hypothesis of this research was that β-adrenoceptor antagonists may interfere with endothelial cell differentiation of stem cells. Specifically, the effects of the non-specific β-adrenergic receptor (β-adrenoceptor) antagonist Propranolol, the β1-adrenoceptor-specific antagonist Atenolol and the β2-adrenoceptor-specific antagonist ICI118,551… CONTINUE READING