β-Sheet Structured β-Amyloid ( 1-40 ) Perturbs Phosphatidylcholine Model Membranes

@inproceedings{Planque2007SheetS,
  title={β-Sheet Structured β-Amyloid ( 1-40 ) Perturbs Phosphatidylcholine Model Membranes},
  author={M. R. R. De Planque and Vincent Raussens and Sonia Antoranz Contera and Dirk T. S. Rijkers and Rob M. J. Liskamp and J. -M. Ruysschaert and John F. Ryan and Frances Separovic and Anthony Watts},
  year={2007}
}
0022-2836/$ see front matter © 2007 E The disruption of intracellular calcium homeostasis plays a central role in the pathology of Alzheimer's disease, which is also characterized by accumulation of the amyloid-β peptides Aβ40 and Aβ42. These amphipathic peptides may become associated with neuronal membranes and affect their barrier function, resulting in the loss of calcium homeostasis. This suggestion has been extensively investigated by exposing protein-free model membranes, either vesicles… CONTINUE READING

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