β-Selection-induced proliferation is required for αβ T cell differentiation.

@article{Kreslavsky2012SelectioninducedPI,
  title={β-Selection-induced proliferation is required for αβ T cell differentiation.},
  author={Taras Kreslavsky and Michael Gleimer and Masaki Miyazaki and Yoon Ju Choi and Etienne Gagnon and Cornelis Murre and Piotr Sicinski and Harald von Boehmer},
  journal={Immunity},
  year={2012},
  volume={37 5},
  pages={840-53}
}
Proliferation and differentiation are tightly coordinated to produce an appropriate number of differentiated cells and often exhibit an antagonistic relationship. Developing T cells, which arise in the thymus from a minute number of bone-marrow-derived progenitors, undergo a major expansion upon pre-T cell receptor (TCR) expression. The burst of proliferation coincides with differentiation toward the αβ T cell lineage-but the two processes were previously thought to be independent from one… CONTINUE READING