β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus.

Abstract

In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against β-secretase (BACE1) with 9.2 × 10⁻⁵  M and K(i) value of 5.5 × 10⁻⁵ M. Loganin exhibited less inhibitory activity to α-secretase (TACE) and other serine proteases exhibiting that it… (More)
DOI: 10.1080/14786419.2012.718774

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