β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

@article{Rothstein2005LactamAO,
  title={β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression},
  author={J. Rothstein and S. Patel and M. Regan and Christine Haenggeli and Y. Huang and D. Bergles and L. Jin and Margaret Dykes Hoberg and S. Vidensky and D. Chung and S. V. Toan and L. Bruijn and Z. Su and P. Gupta and P. Fisher},
  journal={Nature},
  year={2005},
  volume={433},
  pages={73-77}
}
  • J. Rothstein, S. Patel, +12 authors P. Fisher
  • Published 2005
  • Medicine, Biology
  • Nature
  • Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the physiologically dominant astroglial protein. In spite of its critical importance in normal and abnormal synaptic activity, no practical pharmaceutical can positively modulate this protein. Animal studies show that the protein is important for normal excitatory synaptic transmission, while its… CONTINUE READING

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