β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.

@article{Fisher2016LactamRM,
  title={β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.},
  author={Jed F Fisher and Shahriar Mobashery},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2016},
  volume={6 5}
}
The value of the β-lactam antibiotics for the control of bacterial infection has eroded with time. Three Gram-positive human pathogens that were once routinely susceptible to β-lactam chemotherapy-Streptococcus pneumoniae, Enterococcus faecium, and Staphylococcus aureus-now are not. Although a fourth bacterium, the acid-fast (but not Gram-positive-staining) Mycobacterium tuberculosis, has intrinsic resistance to earlier β-lactams, the emergence of strains of this bacterium resistant to… CONTINUE READING
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