β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy.

@article{Aversa2012HydroxymethylbutyrateP,
  title={β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy.},
  author={Zaira Aversa and Nima Alamdari and Estibaliz Castillero and Maurizio Muscaritoli and Filippo Rossi Fanelli and Per Olof Hasselgren},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={423 4},
  pages={
          739-43
        }
}
High levels of glucocorticoids result in muscle wasting and weakness. β-hydroxy-β-methylbutyrate (HMB) attenuates the loss of muscle mass in various catabolic conditions but the influence of HMB on glucocorticoid-induced muscle atrophy is not known. We tested the hypothesis that HMB prevents dexamethasone-induced atrophy in cultured myotubes. Treatment of cultured L6 myotubes with dexamethasone resulted in increased protein degradation and expression of atrogin-1 and MuRF1, decreased protein… CONTINUE READING

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