β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain protocols.

@article{QuintansJnior2013CyclodextrincomplexedP,
  title={β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain protocols.},
  author={Lucindo Jos{\'e} Quintans-J{\'u}nior and Rosana de Souza Siqueira Barreto and Paula dos Passos Menezes and Jackson R. G. S. Almeida and Ana S Viana and Rita de C{\'a}ssia Meneses Oliveira and Alde{\'i}dia P Oliveira and Daniel Pens Gelain and Waldecy de Lucca J{\'u}nior and Adriano Antunes de Souza Ara{\'u}jo},
  journal={Basic & clinical pharmacology & toxicology},
  year={2013},
  volume={113 3},
  pages={167-72}
}
Many plants produce (-)-linalool, a plant-derived monoterpene alcohol, including members of the Lamiaceae (mints) and Lauraceae family (laurels, cinnamon, rosewood). The anti-inflammatory and analgesic effects of (-)-linalool have been widely suggested for various studies. Poor chemical stability and short half-life restrain the clinical applications of some essential oil and monoterpenes, including (-)-linalool. However, β-cyclodextrin (β-CD) has been used to increase solubility and stability… CONTINUE READING
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