β-Cluster haplotypes, α-gene status, and hematological data from SS, SC, and S-β-thalassemia patients in southern California

@inproceedings{Schroeder1989ClusterH,
  title={β-Cluster haplotypes, α-gene status, and hematological data from SS, SC, and S-β-thalassemia patients in southern California},
  author={Walter A. Schroeder and Darleen R. Powars and Lois M. Kay and Linda S. Chan and Van Thanh Huynh and Joan Balog Shelton and Joanna R. Shelton},
  year={1989}
}
The β-gene-cluster haplotype and α-gene status were determined for 221 patients with sickle cell anemia, 41 with SC disease, and 21 with S-β-thalassemia.Among SS patients, eleven βs haplotypes were found in 21 combinations. Three haplotypes — the Benin (Ben) [—+−], the Central African Republic (CAR) [+—−+], and the Senegal (Sen) [+−+++] —comprise 61%, 21%, and 10% of the chromosomes, respectively. Cleavage at the Xmn I sie 5′ to the Gγ gene was observed only when the Senegalese arrangement was… CONTINUE READING

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