β-Cell Growth and Regeneration: Replication Is Only Part of the Story

@inproceedings{BonnerWeir2010CellGA,
  title={β-Cell Growth and Regeneration: Replication Is Only Part of the Story},
  author={Susan Bonner-Weir and Wan-Chun Li and Limor Ouziel-Yahalom and Lili Guo and Gordon C Weir and Arun Sharma},
  booktitle={Diabetes},
  year={2010}
}
For almost a century (for historical review, see 1) both -cell replication and neogenesis (the differentiation of new islet cells from progenitors or stem cells) have been thought to be responsible for postnatal growth of the endocrine pancreas. Even though doubts have been raised in recent years about the existence and importance of neogenesis, this skepticism may be subsiding. Replication and neogenesis are not mutually exclusive. Both processes often occur simultaneously, as seen during the… CONTINUE READING
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Ductal heterogeneity suggests a subpopulation serves as postnatal pancreatic progenitors

  • L Ouziel-Yahalom, WC Li, +4 authors S. Bonner-Weir
  • Diabetes 2010;59(Suppl
  • 2010
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