β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus.

@article{Bluske2012CateninSS,
  title={β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus.},
  author={Krista K. Bluske and Tou Yia Vue and Yasuhiko Kawakami and Makoto Mark Taketo and Kazuaki Yoshikawa and Jane E Johnson and Yasushi Nakagawa},
  journal={Development},
  year={2012},
  volume={139 15},
  pages={2692-702}
}
Neural progenitor cells within the developing thalamus are spatially organized into distinct populations. Their correct specification is critical for generating appropriate neuronal subtypes in specific locations during development. Secreted signaling molecules, such as sonic hedgehog (Shh) and Wnts, are required for the initial formation of the thalamic primordium. Once thalamic identity is established and neurogenesis is initiated, Shh regulates the positional identity of thalamic progenitor… CONTINUE READING