β-Catenin regulates hepatic mitochondrial function and energy balance in mice.

@article{Lehwald2012CateninRH,
  title={β-Catenin regulates hepatic mitochondrial function and energy balance in mice.},
  author={Nadja Corinna Lehwald and G Z Tao and Kyu Yun Jang and Ioanna Papandreou and Bowen Liu and Bo Liu and Marybeth A. Pysz and Juergen K Willmann and Wolfram Trudo Knoefel and Nicholas C. Denko and Karl G. Sylvester},
  journal={Gastroenterology},
  year={2012},
  volume={143 3},
  pages={754-764}
}
BACKGROUND & AIMS Wnt signaling regulates hepatic function and nutrient homeostasis. However, little is known about the roles of β-catenin in cellular respiration or mitochondria of hepatocytes. METHODS We investigated β-catenin's role in the metabolic function of hepatocytes under homeostatic conditions and in response to metabolic stress using mice with hepatocyte-specific deletion of β-catenin and their wild-type littermates, given either saline (sham) or ethanol (as a model of binge… CONTINUE READING
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Conditional  - catenin loss in mice promotes chemical hepatocarcinogenesis : role of oxidative stress and platelet - derived growth factor receptor  / phosphoinositide 3 - kinase signaling

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Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C 3 H 10 T 1 / 2 cells

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