β-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis
@article{Saegusa2001CateninMA, title={β-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis}, author={M. Saegusa and M. Hashimura and T. Yoshida and I. Okayasu}, journal={British Journal of Cancer}, year={2001}, volume={84}, pages={209 - 217} }
To clarify the possible role of aberrant β-catenin expression during endometrial tumorigenesis, a total of 199 cases of endometrial carcinomas (endometrioid type), as well as 37 cases of simple/complex and 32 of atypical hyperplasias, was consecutively investigated for immunohistochemistry, along with 141 normal endometrial samples distant from carcinomas. Of 199 carcinoma cases, 73 tumours as well as 44 normal samples were also analysed using a combination of RT-PCR and Southern blot… CONTINUE READING
Figures, Tables, and Topics from this paper
164 Citations
Mutation of β-catenin gene in endometrial cancer but not in associated hyperplasia
- Medicine
- Medical Electron Microscopy
- 2002
- 34
- Highly Influenced
PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.
- Biology, Medicine
- Human pathology
- 2004
- 15
Abnormalities of the APC/β-catenin pathway in endometrial cancer
- Biology
- Oncogene
- 2002
- 202
- Highly Influenced
- PDF
Loss of &ggr;-Catenin Expression in Squamous Differentiation in Endometrial Carcinomas
- Biology, Medicine
- International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
- 2002
- 5
Nuclear expression of β‐catenin in endometrial hyperplasia as marker of premalignancy
- Medicine
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- 2019
- 15
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
- Biology, Medicine
- Cancer research
- 2001
- 249
- PDF
Mutation and Altered Expression of &bgr;-Catenin During Gallbladder Carcinogenesis
- Biology, Medicine
- The American journal of surgical pathology
- 2002
- 59
Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin
- Biology, Medicine
- Modern Pathology
- 2009
- 49
- PDF
Abnormal Expression of PICT-1 and Its Codon 389 Polymorphism Is a Risk Factor for Human Endometrial Cancer
- Biology, Medicine
- Oncology
- 2018
- 3
References
SHOWING 1-10 OF 87 REFERENCES
Mutations of the β‐Catenin Gene in Endometrial Carcinomas
- Biology, Medicine
- Japanese journal of cancer research : Gann
- 1999
- 103
Mutations of the β‐Catenin Gene in Endometrial Carcinomas
- Biology, Medicine
- Japanese journal of cancer research : Gann
- 1999
- 103
Beta-catenin mutation in carcinoma of the uterine endometrium.
- Biology, Medicine
- Cancer research
- 1998
- 378
Beta-catenin mutation in carcinoma of the uterine endometrium.
- Biology, Medicine
- Cancer research
- 1998
- 378
Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours
- Biology, Medicine
- Virchows Archiv
- 1997
- 120
Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumours
- Biology, Medicine
- Virchows Archiv
- 1997
- 120
Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma.
- Biology, Medicine
- Cancer research
- 1999
- 312
Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma.
- Biology, Medicine
- Cancer research
- 1999
- 312