β-Catenin binds to the downstream region and regulates the expression C-reactive protein gene

@inproceedings{Choi2007CateninBT,
  title={β-Catenin binds to the downstream region and regulates the expression C-reactive protein gene},
  author={Yong Seok Choi and Jung Ho Hur and Sunjoo Jeong},
  booktitle={Nucleic acids research},
  year={2007}
}
C-Reactive protein (CRP) is a major acute-phase response protein, which is activated by various cytokines. We investigated the mechanism of TNF-alpha-induced CRP expression and found that the p50 subunit of NF-kappaB was responsible for the transcriptional activation of CRP. Since the p50 protein acts as a positive regulator of CRP expression without an inherent transactivation domain, we looked for an interaction partner that could provide p50 with such a domain. We found that beta-catenin… CONTINUE READING

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Distinct role of PI3-kinase/ Akt pathway in the activation of etoposide-induced NF-kB transcription factor

Y. S. Choi, H. Park, S. Jeong
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