β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation

@article{Ahmad2011CateninAS,
  title={β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation},
  author={Imran Ahmad and Jennifer P Morton and Lukram Babloo Singh and Sorina Radulescu and Rachel A. Ridgway and Sejal Patel and James R Woodgett and Douglas J Winton and Makato M Taketo and X. Wu and Hing Y Leung and Owen James Sansom},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={178-189}
}
Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its importance, we have targeted expression of an activated form of β-catenin to the urothelium of transgenic mice using Cre–Lox technology (UroIICRE+ β-cateninexon3/+). Expression of this activated form of β-catenin led to the formation of localized hyperproliferative lesions by 3 months, which did not progress to malignancy. These lesions… CONTINUE READING

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Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006
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