β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.

@article{Mastrogiannaki2016CateninSI,
  title={β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.},
  author={Maria Mastrogiannaki and Beate Maria Lichtenberger and Andreas Reimer and Charlotte A. Collins and Ryan R Driskell and Fiona M Watt},
  journal={The Journal of investigative dermatology},
  year={2016},
  volume={136 6},
  pages={
          1130-1142
        }
}
The Wnt/β-catenin pathway plays a central role in epidermal homeostasis and regeneration, but how it affects fibroblast fate decisions is unknown. We investigated the effect of targeted β-catenin stabilization in dermal fibroblasts. Comparative gene expression profiling of stem cell antigen 1(-) (Sca1(-)) and Sca1(+) neonatal fibroblasts from upper and lower dermis, respectively, confirmed that Sca1(+) cells had a preadipocyte signature and showed differential expression of Wnt/β-catenin… CONTINUE READING

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