β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4.

@article{Funa2015CateninRP,
  title={β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4.},
  author={Nina S Funa and Karen A Schachter and Mads Lerdrup and J. A. O. Ekberg and Katja Hess and N. Dietrich and Christian Honor{\'e} and Klaus H. Hansen and Henrik Semb},
  journal={Cell stem cell},
  year={2015},
  volume={16 6},
  pages={639-52}
}
Canonical Wnt and Nodal signaling are both required for induction of the primitive streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is thought to function in these early lineage specification decisions via transcriptional activation of Nodal signaling. Here, we demonstrate a broader role for β-catenin in PS formation by analyzing its genome-wide binding in a human embryonic stem cell model of PS induction. β-catenin occupies regulatory regions in numerous… CONTINUE READING
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Dose-dependent Nodal/Smad signals pattern the early mouse embryo.

Seminars in cell & developmental biology • 2014
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