β-Catenin N- and C-terminal Tails Modulate the Coordinated Binding of Adherens Junction Proteins to β-Catenin*

@article{Castao2002CateninNA,
  title={$\beta$-Catenin N- and C-terminal Tails Modulate the Coordinated Binding of Adherens Junction Proteins to $\beta$-Catenin*},
  author={Julio Casta{\~n}o and Imma Raurell and José A. Piedra and Susana Miravet and Mireia Du{\~n}ach and Antonio Garcı́a de Herreros},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={31541 - 31550}
}
β-Catenin plays a central role in the establishment and regulation of adherens junctions because it interacts with E-cadherin and, through α-catenin, with the actin cytoskeleton. β-Catenin is composed of three domains: a central armadillo repeat domain and two N- and C-terminal tails. The C-tail interacts with the armadillo domain and limits its ability to bind E-cadherin and other cofactors. The two β-catenin tails are mutually inter-regulated because the C-tail is also necessary for binding… 

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