β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

@article{Huelsken2001CateninCH,
  title={β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin},
  author={J. Huelsken and R. Vogel and B. Erdmann and G. Cotsarelis and W. Birchmeier},
  journal={Cell},
  year={2001},
  volume={105},
  pages={533-545}
}
  • J. Huelsken, R. Vogel, +2 authors W. Birchmeier
  • Published 2001
  • Biology, Medicine
  • Cell
  • beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We show that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and… CONTINUE READING
    1,164 Citations
    beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.
    • 239
    Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling
    • 45
    • PDF
    Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate
    • 163
    • PDF
    Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
    • 221
    • PDF
    Hairless controls hair fate decision via Wnt/β-catenin signaling.
    • 2
    Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development
    • 9
    • Highly Influenced
    β-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
    • 49
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 159 REFERENCES
    De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
    • 1,077
    Essential role for Sonic hedgehog during hair follicle morphogenesis.
    • 477
    Sonic hedgehog signaling is essential for hair development
    • 701
    WNT signaling in the control of hair growth and structure.
    • 255
    • PDF
    Noggin is a mesenchymally derived stimulator of hair-follicle induction
    • 381
    beta-catenin signaling can initiate feather bud development.
    • 150
    Splitting Hairs Dissecting Roles of Signaling Systems in Epidermal Development
    • 151
    • Highly Influential