β-Catenin—A Linchpin in Colorectal Carcinogenesis?

@inproceedings{Wong2002CateninALI,
  title={β-Catenin—A Linchpin in Colorectal Carcinogenesis?},
  author={Newton A C S Wong and Massimo Pignatelli},
  year={2002}
}
An important role for β-catenin pathways in colorectal carcinogenesis was first suggested by the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of dysregulation of β-catenin protein expression at all stages of the adenoma-carcinoma sequence. Recent studies have, however, shown that yet more components of colorectal carcinogenesis are linked to β-catenin pathways. Pro-oncogenic factors that also release β-catenin from the adherens complex and/or encourage… CONTINUE READING

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