β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products

@article{Kim2013CaryophylleneOP,
  title={β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products},
  author={Chulwon Kim and Somi Kim Cho and Ki-Dong Kim and Dongwoo Nam and Won-Seok Chung and Hyeung-Jin Jang and Seok-Geun Lee and Bum Sang Shim and Gautam Sethi and Kwang Seok Ahn},
  journal={Apoptosis},
  year={2013},
  volume={19},
  pages={708-718}
}
We have recently reported that β-caryophyllene oxide (CPO) can induce apoptosis, suppress tumor growth, and inhibit metastasis through the suppression of signal transducer and activator of transcription 3, PI3K/AKT/mTOR/S6K1 signaling cascades and ROS-mediated MAPKs activation. In the present study, we found that CPO potentiated the apoptosis induced by tumor necrosis factor α (TNFα) and chemotherapeutic agents, suppressed TNFα-induced tumor cell invasion, all of which are known to require NF… CONTINUE READING
7 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice

  • NL Quintao, GF da Silva, CS Antonialli, LW Rocha, V Cechinel Filho, JF Ciccio
  • Planta Med
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…