β-Carotene bioavailability and conversion efficiency are significantly affected by sex in rats. First observation suggesting a possible hormetic regulation of vitamin A metabolism in female rats.

@article{Borel2021CaroteneBA,
  title={$\beta$-Carotene bioavailability and conversion efficiency are significantly affected by sex in rats. First observation suggesting a possible hormetic regulation of vitamin A metabolism in female rats.},
  author={Patrick Borel and Romane Troadec and Morgane Damiani and Charlotte Halimi and Marion Nowicki and Philippe Guichard and Marielle Margier and Julien Astier and Michel Grino and Emmanuelle Reboul and Jean-François Landrier},
  journal={Molecular nutrition \& food research},
  year={2021},
  pages={
          e2100650
        }
}
SCOPE To study the effect of variation in dietary vitamin A (VA) content on its hepatic and intestinal metabolism . METHODS AND RESULTS Adult female and male rats werefed with diets containing 400, 2300, or 9858 IU/kg VA for 31-33 weeks. VA concentrations weremeasured in plasma and liver. Bioavailability and intestinal conversion efficiency of β-carotene to VA wereassessed by measuring postprandial plasma β-carotene and retinyl palmitate concentrations after force-feeding rats with β-carotene… 

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References

SHOWING 1-10 OF 58 REFERENCES
beta-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet.
TLDR
The intestinal dioxygenase activity as measured in vitro is an adequate indicator of in vivo beta-carotene cleavage activity, higher in vitamin A-deficient rats than in rats with a high intake of either vitamin A or beta- carotene.
Absorption and conversion of 11,12-(3)H-beta-carotene to vitamin A in Sprague-Dawley rats of different vitamin A status.
TLDR
The results suggest that a single oral dose of beta-carotene might not be an effective way of raising vitamin A stores in the body.
Absorption and retinol equivalence of beta-carotene in humans is influenced by dietary vitamin A intake.
TLDR
While less cleavage of beta-carotene occurred due to vitamin A supplementation, higher absorption resulted in larger molar vitamin A values.
Influence of retinoid nutritional status on cellular retinol- and cellular retinoic acid-binding protein concentrations in various rat tissues.
TLDR
CRBP metabolism and levels appear to be minimally influenced by the amount or kind of retinoid ligand available or by sex, while CRABP levels showed no diet- or sex-dependent differences.
Vitamin A deficiency reduces uptake of beta-carotene by brush border membrane vesicles but does not alter intestinal retinyl ester hydrolase activity in the rat.
TLDR
The data suggest that vitamin A deficiency impairs enterocyte membrane uptake of beta-carotene without altering the enzymatic activity of intrinsic REH.
Hepatic and plasma sex differences in saturated and monounsaturated fatty acids are associated with differences in expression of elongase 6, but not stearoyl-CoA desaturase in Sprague–Dawley rats
TLDR
Sex differences in MUFA composition were associated with increased expression of hepatic elongase 6 in females relative to male rats, which appears to be mediated by sex hormones based on observations of hormonal treatments of HepG2 cells.
Regulation of retinol-binding protein metabolism by vitamin A status in the rat.
TLDR
It is suggested that vitamin A deficiency primarily interferes in some way with the secretion, rather than with the synthesis, of RBP by the liver, and that the deficient liver contains a pool of previously formed apo-RBP which can be released rapidly into the serum, as holo- RBP, when vitamin A becomes available.
ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice.
TLDR
ABCA1 is the transporter responsible for the in vivo secretion of alpha- and gamma-tocopherol with intestinal HDL, and this pathway is significantly implicated in the intestinal absorption and plasma status of vitamin E but not of vitamin A.
Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability
TLDR
Much work remains to be done to identify all of the SNPs involved in VA status and bioavailability and to assess the possible involvement of other kinds of genetic variations, e.g., copy number variants and insertions/deletions, in these phenotypes.
Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status.
TLDR
Lecithin:retinol acyltransferase (LRAT) and CYP26 serve as two molecular mechanisms, coordinately regulated by all-trans-RA, to control the availability of retinol and RA, respectively.
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