β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

@article{Fereshteh2012Arrestin2MT,
  title={β-Arrestin2 mediates the initiation and progression of myeloid leukemia.},
  author={Mark Fereshteh and Takahiro Ito and Jeffrey J. Kovacs and Chen Zhao and Hyog Young Kwon and Valerie A. Tornini and Takaaki Konuma and M M Chen and Robert J Lefkowitz and Tannishtha Reya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 31},
  pages={
          12532-7
        }
}
β-Arrestins were initially discovered as negative regulators of G protein-coupled receptor signaling. Although β-arrestins have more recently been implicated as scaffold proteins that interact with various mitogenic and developmental signals, the genetic role of β-arrestins in driving oncogenesis is not known. Here we have investigated the role of β-arrestin in hematologic malignancies and have found that although both β-arrestin1 and -2 are expressed in the hematopoietic system, loss of… CONTINUE READING

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