β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis

@article{Zeng2015Arrestin2EI,
  title={β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis},
  author={Lilan Zeng and Jun Tao and Hui Ling Liu and Si Wei Tan and Young Duk Yang and Xiaojun Peng and Zhao hui Liu and Jie Jiang and Bin Wu},
  journal={Mucosal Immunology},
  year={2015},
  volume={8},
  pages={683-695}
}
β-Arrestins (β-arrs) are regulators and mediators of G protein-coupled receptor signaling, and accumulating evidence suggests that they are functionally involved in inflammation and autoimmune diseases. However, the effect of β-arrs is unclear in inflammatory bowel disease (IBD), and the role of β-arr2 is unknown in ulcerative colitis (UC) and Crohn’s disease (CD). The aim of this study is to investigate whether β-arr2 encourages inflammation-induced epithelial apoptosis through endoplasmic… CONTINUE READING
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