β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking

@inproceedings{Shintani2018Arrestin1A2,
  title={β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking},
  author={Yoshiaki Shintani and Atsuko Hayata-Takano and Keita Moriguchi and Takanobu Nakazawa and Yukio Ago and Atsushi Kasai and Kaoru Seiriki and Norihito Shintani and Hitoshi Hashimoto},
  booktitle={PloS one},
  year={2018}
}
A pituitary adenylate cyclase-activating polypeptide (PACAP)-specific receptor, PAC1R, is coupled with multiple signal transduction pathways including stimulation of adenylate cyclase, phospholipase C and extracellular-signal regulated kinase (ERK)1/2. PAC1R has been shown to exert its long-lasting and potent signals via β-arrestin1 and β-arrestin2. However, the precise roles of the two β-arrestin isoforms in PACAP-PAC1R signaling remain unclear. Here we examined the interaction between the two… CONTINUE READING
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