β-Arrestin Regulates Estradiol Membrane-Initiated Signaling in Hypothalamic Neurons

Abstract

Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization. While ß-arrestin-mediated mERα internalization has been described in the cortex, a role of ß-arrestin in… (More)
DOI: 10.1371/journal.pone.0120530

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@inproceedings{Wong2015ArrestinRE, title={β-Arrestin Regulates Estradiol Membrane-Initiated Signaling in Hypothalamic Neurons}, author={Angela Wong and Matthew C. Abrams and Paul E Micevych}, booktitle={PloS one}, year={2015} }