β-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum

@article{Li2013Arrestin2IP,
  title={β-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum},
  author={Haohong Li and Yezheng Tao and Li Ma and Xing Liu and Lan Ma},
  journal={Neuroscience Bulletin},
  year={2013},
  volume={29},
  pages={531-540}
}
In this study, we investigated the role of β-arrestin-2 in alcohol preference using the two-bottle choice and conditioned place preference procedures in wild-type (WT) and β-arrestin-2 knockout (KO) mice. Locomotion and righting reflex tests were performed to test alcohol sensitivity. The possible molecular signals regulated by β-arrestin-2 were analyzed by Western blot. We found that β-arrestin-2 KO mice showed a marked increase in voluntary alcohol consumption without significant differences… CONTINUE READING

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