β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: the first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursors.

@article{Kunii2012AmyrinOB,
  title={β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: the first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursors.},
  author={Mieko Kunii and Yutaka Kitahama and Ery Odette Fukushima and Hikaru Seki and Toshiya Muranaka and Yuzo Yoshida and Yuri Aoyama},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 5},
  pages={801-4}
}
CYP51 has been recognized as a unique CYP family that consists of one isolated molecular species, a sterol 14-demethylase essential for sterol biosynthesis. However, another CYP51 gene classified as the CYP51H subfamily has been identified in higher plants, in addition to a sterol 14-demethylase gene, CYP51G1. To shed light on the function of this "second CYP51", oat CYP51H10 was introduced into the β-amyrin-producing yeast cells, and the effect of the expressed CYP51H10 on β-amyrin metabolism… CONTINUE READING

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