β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.

@article{Khan2013AdrenergicRO,
  title={β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.},
  author={Mohsin U. Khan and Sadia Mohsin and Daniele Avitabile and Sailay Siddiqi and Jonathan Nguyen and Kathleen Wallach and Pearl Quijada and Michael A. McGregor and Natalie A. Gude and Roberto L. Alvarez and Douglas G. Tilley and Walter J Koch and Mark A Sussman},
  journal={Circulation research},
  year={2013},
  volume={112 3},
  pages={476-86}
}
RATIONALE Short-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death. Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of long-term β-adrenergic drive on CPC survival and proliferation are unknown. OBJECTIVE We sought to determine the relationship between β-adrenergic activity and regulation of CPC function. METHODS… CONTINUE READING
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