β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.

@article{Sucharov2011AdrenergicRS,
  title={β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.},
  author={Carmen C. Sucharov and Karen Dockstader and Karin R Nunley and Timothy A McKinsey and Michael Bristow},
  journal={Journal of cardiac failure},
  year={2011},
  volume={17 7},
  pages={592-600}
}
INTRODUCTION Chronic activation of β(1)-adrenergic receptor (β(1)-AR) signaling can have deleterious effects on the heart, and animal models overexpressing β(1)-ARs develop a dilated cardiomyopathy and heart failure. In the classic β-AR pathway, receptor occupancy by an agonist results in increased cyclic adenosine monophosphate (cAMP) levels and activation of protein kinase A (PKA). However, the role of PKA-dependent signaling in the development and progression of cardiomyopathies and heart… CONTINUE READING