β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment

@article{Bednarek2011AdducinIR,
  title={$\beta$-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment},
  author={Ewa Bednarek and Pico Caroni},
  journal={Neuron},
  year={2011},
  volume={69},
  pages={1132-1146}
}

Figures from this paper

Learning-related feedforward inhibitory connectivity growth required for memory precision
TLDR
It is shown that one-trial and incremental learning lead to robust, circuit-specific, long-lasting and reversible increases in the numbers of filopodial synapses onto fast-spiking interneurons that trigger feedforward inhibition.
The function of Copine 6 in the brain
TLDR
Copine 6 is identified as an important player in the regulation of synaptic plasticity in vitro and in vivo and may regulate long-term adaptations in neuronal functions that involve transcriptional regulations.
A role for α‐adducin (ADD‐1) in nematode and human memory
TLDR
It is shown that α‐adducin is required for consolidation of synaptic plasticity, for sustained synaptic increase of AMPA‐type glutamate receptor (GLR‐1) content and altered GLR•1 turnover dynamics and genetic variability of the human ADD1 gene was significantly associated with episodic memory performance in healthy young subjects.
The actin cytoskeleton in memory formation
GluN3A Promotes Dendritic Spine Pruning and Destabilization during Postnatal Development
TLDR
Confocal time-lapse imaging data provide strong evidence that GluN3A prevents the activity-dependent stabilization of synapses thereby promoting spine pruning, and suggest that Glamorganised Glu3A expression operates as a molecular signal for controlling the extent and timing of synapse maturation.
Alteration of Synaptic Network Dynamics by the Intellectual Disability Protein PAK3
TLDR
This work identifies a novel function of PAK3 in regulating activity-mediated rearrangement of synaptic connectivity associated with learning and suggests that defects in spine formation and refinement during development could account for intellectual disability.
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
TLDR
An unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR -34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus
TLDR
The role of extracellular proteolysis in various aspects of synaptic plasticity in hippocampal mossy fiber synapses is reviewed, and a growing body of evidence demonstrates that among perisynaptic proteases, tissue plasminogen activator (tPA)/plasmin system, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and metalloproteinases play a crucial role in shaping plastic changes in this projection.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
TLDR
Results indicate that β-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
β‐adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the α‐ and γ‐adducin subunits
TLDR
The results strongly suggest coordinated expression and phosphorylation of adducin subunits as a key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
Learning-related feedforward inhibitory connectivity growth required for memory precision
TLDR
It is shown that one-trial and incremental learning lead to robust, circuit-specific, long-lasting and reversible increases in the numbers of filopodial synapses onto fast-spiking interneurons that trigger feedforward inhibition.
Protracted Synaptogenesis after Activity-Dependent Spinogenesis in Hippocampal Neurons
TLDR
This study examines the first few hours after activity-dependent spinogenesis by correlating time-lapse two-photon microscopy of newly formed spines on CA1 pyramidal neurons in organotypic hippocampal slices with electron microscopy and shows that older spines consistently have ultrastructural hallmarks typical of synapses.
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
TLDR
It is concluded that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory.
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
TLDR
It is shown that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks
TLDR
High-frequency stimulation can make stable presynaptic terminals become dynamic, providing a candidate mechanism to convert experience into changes in network connectivity.
Stably maintained dendritic spines are associated with lifelong memories
TLDR
It is shown that learning and daily sensory experience leave minute but permanent marks on cortical connections and suggest that lifelong memories are stored in largely stably connected synaptic networks.
...
...