β-Actin knock-out mouse embryonic fibroblasts show increased expression of LIM-, CH-, EFh-domain containing proteins with predicted common upstream regulators.

@article{Ampe2013ActinKM,
  title={β-Actin knock-out mouse embryonic fibroblasts show increased expression of LIM-, CH-, EFh-domain containing proteins with predicted common upstream regulators.},
  author={Christophe Ampe and Jelle Libbrecht and Marleen Van Troys},
  journal={Cytoskeleton},
  year={2013},
  volume={70 11},
  pages={
          766-74
        }
}
  • Christophe Ampe, Jelle Libbrecht, Marleen Van Troys
  • Published in Cytoskeleton 2013
  • Medicine, Biology
  • β-actin depletion from mouse embryonic fibroblasts results in an altered transcriptional response rendering these cells a myofibroblast like phenotype. The proteins and upstream regulatory factors responsible for this acquired phenotype, with prominent focal adhesions and stress fibres, are unknown. Data-mining of the changed proteome revealed that actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the β-actin knock-out cells and that many of… CONTINUE READING

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