β-1,3-Glucan recognition protein (βGRP) is essential for resistance against fungal pathogen and opportunistic pathogenic gut bacteria in Locusta migratoria manilensis.

@article{Zheng201213GlucanRP,
  title={β-1,3-Glucan recognition protein (βGRP) is essential for resistance against fungal pathogen and opportunistic pathogenic gut bacteria in Locusta migratoria manilensis.},
  author={Xiaoli Zheng and Yuxian Xia},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={36 3},
  pages={602-9}
}
Pattern recognition proteins, which form part of the innate immune system, initiate host defense reactions in response to pathogen surface molecules. The pattern recognition protein β-1,3-glucan recognition protein (βGRP) binds to β-1,3-glucan on fungal surfaces to mediate melanization via the prophenoloxidase (PPO)-activating cascade. In this study, cDNA encoding a 53-kDa βGRP (LmβGRP) was cloned from Locusta migratoria manilensis. LmβGRP mRNA shown to be constitutively expressed specifically… CONTINUE READING
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