β(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation?

@article{Insel20112AdrenergicRP,
  title={β(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation?},
  author={Paul A. Insel},
  journal={Science signaling},
  year={2011},
  volume={4 185},
  pages={pe37}
}
Nonsynonymous, coding sequence single-nucleotide polymorphisms in β(2)-adrenergic receptors were first recognized almost 20 years ago, but a full understanding of their impact on signal transduction-especially on receptor abundance in native cells and their clinical importance-remains unclear. New evidence has revealed a feature of the Arg(16)Gly variant of β(2)-adrenergic receptors that has not been previously noted: a difference in the rate of response upon repeated stimulation of the… CONTINUE READING