β₂-Glycoprotein I inhibits endothelial cell migration through the nuclear factor κB signalling pathway and endothelial nitric oxide synthase activation.

@article{Chiu2012GlycoproteinII,
  title={β₂-Glycoprotein I inhibits endothelial cell migration through the nuclear factor κB signalling pathway and endothelial nitric oxide synthase activation.},
  author={Wen-Chin Chiu and Tzeon-Jye Chiou and A H Chiang},
  journal={The Biochemical journal},
  year={2012},
  volume={445 1},
  pages={125-33}
}
β₂-GPI (β₂-glycoprotein I) is a plasma glycoprotein ascribed with an anti-angiogenic function; however, the biological role and molecular basis of its action in cell migration remain unknown. The aim of the present study was to assess the contribution of β₂-GPI to HAEC (human aortic endothelial cell) migration and the details of its underlying mechanism. Using wound healing and Boyden chamber assays, we found that β₂-GPI inhibited endothelial cell migration, which was restored by its… CONTINUE READING
5 Extracted Citations
52 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…