β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.

@article{Eke2012IntegrinFAKcortactinSI,
  title={β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.},
  author={I. P. Eke and Yvonne Deuse and Stephanie Hehlgans and Kristin Gurtner and Mechthild Krause and Michael Baumann and Anna Shevchenko and Veit Sandfort and Nils Cordes},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 4},
  pages={
          1529-40
        }
}
Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of β₁ integrins with inhibitory antibodies enhances the sensitivity to ionizing radiation and delays the growth of human head and neck squamous cell carcinoma cell lines in 3D cell culture and in xenografted mice. Mechanistically, dephosphorylation of focal adhesion kinase (FAK) upon inhibition of β₁ integrin resulted in dissociation of a FAK/cortactin… CONTINUE READING

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