β‐Elemene inhibits 7,12‐dimethylbenz(a)anthracene/12‐O‐tetradecanoylphorbol‐13‐acetate‐induced skin tumorigenesis through suppression of NF‐κB‐associated signaling events in the mouse skin model

@article{Hu2020ElemeneI7,
  title={$\beta$‐Elemene inhibits 7,12‐dimethylbenz(a)anthracene/12‐O‐tetradecanoylphorbol‐13‐acetate‐induced skin tumorigenesis through suppression of NF‐$\kappa$B‐associated signaling events in the mouse skin model},
  author={Xing Hu and Liang Wang and Lili Zhang and Tao Zhang},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={2020},
  volume={34}
}
β‐Elemene (1‐methyl‐1‐vinyl‐2,4‐diisopropenyl‐cyclohexane), a natural sesquiterpene‐derived curcumae radix, exhibits a variety of pharmacologic properties including anticancer. However, the molecular action of β‐elemene in chemical‐induced skin carcinogenesis remains unclear. Therefore, the present study executes to investigate a possible effect of β‐elemene in the 7,12‐dimethylbenz(a)anthracene (DMBA)/12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐promoted skin tumor model. The experimental mice… 
A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology
Curcumae Radix is an efficacious ingredient with various medicinal properties empirically used in traditional Chinese medicine (TCM) formula for the treatment of cancer, depression, chest pain,

References

SHOWING 1-10 OF 77 REFERENCES
[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis
TLDR
It is concluded that shogaol prevents DMBA‐induced HBP carcinogenesis through its antioxidant as well as modulating apoptotic signals.
Inhibitory effect of garcinol against 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice
Abstract Garcinol, a polyisoprenylated benzophenone derivative, is one of the major constituents isolated from the Garcinia indica fruit rind. Previous studies have reported that garcinol exhibits
13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells
TLDR
It is verified that IIi is cytotoxic to a wide spectrum of human cancer cells in culture, including those of breast, ovarian, lung, gastric, hepatocellular and colon cancer, as well as leukemia cell lines, and shown to be a novel potential antitumor agent.
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice
TLDR
Zerumbone is a promising agent for the prevention of both tumor initiating and promoting processes, through induction of anti‐oxidative and phase II drug metabolizing enzymes as well as attenuation of proinflammatory signaling pathways.
Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study
TLDR
Evaluated lipid peroxidation (LPO) levels indicate the pro-oxidative nature of Silibinin in the cancerous tissue, supporting the theory of augmented LPO levels resulting in increased apoptosis in the skin tumors treated with SilibInin.
Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
TLDR
It is suggested that Lupeol is an attractive antitumor-promoting agent that must be evaluated in tumor models other than skin carcinogenesis, and inhibits conventional as well as novel biomarkers of tumor promotion.
The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.
TLDR
The data indicate that topical application of euphol markedly inhibits the inflammatory response induced by TPA, indicating that euphol represents a promising agent for the management of skin diseases with an inflammatory component.
Folic Acid Modulates DMBA/TPA–Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis
TLDR
Findings suggest the inhibitory potential of FA during initial stages of murine skin cancer, and detailed studies are warranted considering the ambiguous reports available in literature regarding the association of FA and cancer.
β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway.
TLDR
A pathway of procaspase‑3-β-ELE function that involves decreased mitochondrial membrane potential, leading to apoptosis triggered by the release of cytochrome c into the cytoplasm and the modulation of apoptosis-related genes is defined.
[6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis.
  • G. Annamalai, K. Suresh
  • Medicine, Biology
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2018
TLDR
Investigation of the effect of [6]-SHO on inflammation and cell proliferation by inhibiting the translocation of NF-κB and AP-1 in DMBA induced HBP carcinogenesis suggested that [6]SHO is a novel functional agent capable of preventingDMBA induced inflammation andcell proliferation associated tumorigenesis by modulating multiple signalling molecules.
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