αPS2 integrin-mediated muscle attachment in Drosophila requires the ECM protein Thrombospondin

@article{Chanana2007PS2IM,
  title={αPS2 integrin-mediated muscle attachment in Drosophila requires the ECM protein Thrombospondin},
  author={Bhavna Chanana and Roland Graf and Tatyana Y Koledachkina and Ralf Pflanz and Gerd Vorbrueggen},
  journal={Mechanisms of Development},
  year={2007},
  volume={124},
  pages={463-475}
}
During Drosophila embryogenesis, the attachment of somatic muscles to epidermal tendon cells requires heterodimeric PS-integrin proteins (alpha- and beta-subunits). The alpha-subunits are expressed complementarily, either tendon cell- or muscle-specific, whereas the beta-integrin subunit is expressed in both tissues. Mutations of beta-integrin cause a severe muscle detachment phenotype, whereas alpha-subunit mutations have weaker or only larval muscle detachment phenotypes. Furthermore… CONTINUE READING

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