αNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia

@article{Hotokezaka2009NACDA,
  title={αNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia},
  author={Yuka Hotokezaka and Klaus van Leyen and Eng H. Lo and Birgitta Beatrix and Ichiro Katayama and Guifang Jin and Toshihisa Nakamura},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={1505-1514}
}
Accumulation of unfolded proteins triggers endoplasmic reticulum (ER) stress and is considered a part of the cellular responses to hypoxia. The nascent polypeptide-associated complex (NAC) participates in the proper maturation of newly synthesized proteins. However, thus far, there have been no comprehensive studies on NAC involvement in hypoxic stress. Here, we show that hypoxia activates glycogen synthase kinase-3β (GSK-3β) and that the activated GSK-3β destabilizes αNAC with the subsequent… CONTINUE READING