αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy.

@article{Shi2016KlothoMP,
  title={αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy.},
  author={Mingjun Shi and Brianna Flores and Nancy Gillings and Ao Bian and Han Jun Cho and Shirley Yan and Yang Liu and Beth Levine and Orson W Moe and Ming Chang Hu},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 8},
  pages={2331-45}
}
AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI progression to CKD has not been studied. We altered systemic αKlotho levels by genetic manipulation, phosphate loading, or aging and examined the effect on long-term outcome after AKI in two models: bilateral ischemia-reperfusion injury and unilateral nephrectomy plus contralateral ischemia-reperfusion injury… CONTINUE READING
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