αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish

@inproceedings{Han2016EcatenindependentMI,
  title={αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish},
  author={Mitchell K. L. Han and Esteban Hoijman and Emily S No{\"e}l and Laurence Garric and Jeroen Bakkers and Johan de Rooij},
  booktitle={Biology open},
  year={2016}
}
Cadherin complexes mediate cell-cell adhesion and are crucial for embryonic development. Besides their structural function, cadherin complexes also transduce tension across the junction-actomyosin axis into proportional biochemical responses. Central to this mechanotransduction is the stretching of the cadherin-F-actin-linker α-catenin, which opens its central domain for binding to effectors such as vinculin. Mechanical unfolding of α-catenin leads to force-dependent reinforcement of cadherin… CONTINUE READING

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