αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma.

@article{Huang2013BcrystallinCW,
  title={αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma.},
  author={Xiao-Yong Huang and Ai-Wu Ke and Guo-Ming Shi and Xin Zhang and Chi Zhang and Ying-hong Shi and Xiaoying Wang and Zhen-bin Ding and Yong-sheng Xiao and Jun Yan and Shuang-jian Qiu and Jia Fan and Jian Zhou},
  journal={Hepatology},
  year={2013},
  volume={57 6},
  pages={2235-47}
}
UNLABELLED The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular pathogenesis remains incompletely defined in HCC. Here we report that increased expression of αB-Crystallin in human HCC predicts poor survival and disease recurrence after surgery. Multivariate analysis identifies αB-Crystallin expression as an independent predictor for postoperative recurrence and overall survival. We show that elevated expression of αB-Crystallin promotes HCC… CONTINUE READING

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