αA-crystallin gene CpG islands hypermethylation in nuclear cataract after pars plana vitrectomy

@article{Zhu2015AcrystallinGC,
  title={αA-crystallin gene CpG islands hypermethylation in nuclear cataract after pars plana vitrectomy},
  author={Xiang-Jia Zhu and Ke-Ke Zhang and Peng Zhou and Chun-hui Jiang and Yi Lu},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2015},
  volume={253},
  pages={1043-1051}
}
To investigate the DNA methylation status of αA-crystallin gene in cataract secondary to pars plana vitrectomy. Anterior capsular membranes of 40 eyes of 40 patients with cataract secondary to vitrectomy were collected. Another 20 eyes of 20 patients who received pars plana vitrectomy and phacoemulsification in the primary procedure, were recruited as control. Methylation status of the CpG islands of αA-crystallin gene was analyzed by pyrosequencing. Expression of αA-crystallin was evaluated by… CONTINUE READING

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