α9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis1

@article{Kanayama20099IA,
  title={$\alpha$9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis1},
  author={Masashi Kanayama and Daisuke Kurotaki and Junko Morimoto and Tsuyoshi Asano and Yutaka Matsui and Yosuke Nakayama and Yoshinari Saito and Koyu Ito and Chiemi Kimura and Norimasa Iwasaki and Koji Suzuki and Tanenobu Harada and Hong Mei Li and Jun Uehara and Tadaaki Miyazaki and Akio Minami and Shigeyuki Kon and Toshimitsu Uede},
  journal={The Journal of Immunology},
  year={2009},
  volume={182},
  pages={8015 - 8025}
}
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to the inflammatory joint destruction is largely unknown. We found that not only osteopontin but also tenascin-C and their common receptor, α9 integrin, are expressed at arthritic joints. The local production of osteopontin and tenascin-C is mainly due to synovial fibroblasts and, to a lesser extent, synovial macrophages. Synovial fibroblasts and… 

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