α9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis1

@article{Kanayama20099IA,
  title={$\alpha$9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis1},
  author={M. Kanayama and D. Kurotaki and J. Morimoto and T. Asano and Y. Matsui and Yosuke Nakayama and Yoshinari Saito and Koyu Ito and C. Kimura and N. Iwasaki and Koji Suzuki and T. Harada and H. M. Li and J. Uehara and T. Miyazaki and A. Minami and S. Kon and T. Uede},
  journal={The Journal of Immunology},
  year={2009},
  volume={182},
  pages={8015 - 8025}
}
Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin and joint cell components that leads to the inflammatory joint destruction is largely unknown. We found that not only osteopontin but also tenascin-C and their common receptor, α9 integrin, are expressed at arthritic joints. The local production of osteopontin and tenascin-C is mainly due to synovial fibroblasts and, to a lesser extent, synovial macrophages. Synovial fibroblasts and… Expand
α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
TLDR
Findings indicate that autocrine and paracrine interaction of α9β1 integrin and tenascin-C in the joint tissue microenvironment contributes to the pathogenesis of RA and may become a potential therapeutic target for RA. Expand
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TLDR
The central role ofα9 in pathogenic behaviors of RA-FLSs is demonstrated and the potential of α9-blocking agents as a nonimmunosuppressive treatment for RA-associated synovitis is highlighted. Expand
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  • Biology, Medicine
  • Journal of Cell Communication and Signaling
  • 2017
TLDR
The role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases is focused on. Expand
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TLDR
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TLDR
Recent progress in understanding of Osteopontin's role in variety of inflammatory disorders is summarized. Expand
Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases
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  • Biology, Medicine
  • Pathology international
  • 2011
TLDR
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Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease.
TLDR
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Tenascin-C Function in Glioma: Immunomodulation and Beyond.
TLDR
Clinically, tenascin-C can serve as a biomarker for tumor progression; and TNC antibodies have been utilized as an adjuvant agent to deliver anti-tumor drugs to target glioma. Expand
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