α9β1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation

@article{Kanayama201191IS,
  title={$\alpha$9$\beta$1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation},
  author={M. Kanayama and J. Morimoto and Y. Matsui and Masahiro Ikesue and Keiko Danzaki and D. Kurotaki and Koyu Ito and Toshimichi Yoshida and T. Uede},
  journal={The Journal of Immunology},
  year={2011},
  volume={187},
  pages={5851 - 5864}
}
The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) and integrins has been implicated in the pathology of rheumatoid arthritis in which Th17 cells are recognized as primary pathogenic cells. The differentiation of Th17 cells is tightly regulated by cytokines derived from APCs, receiving various signals including TLR stimuli. In this study, we used a collagen-induced arthritis model and found that increased numbers of α9 integrin-positive conventional… Expand
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