α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease.

@article{Kawamata20127NA,
  title={α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease.},
  author={Jun Kawamata and Syuuichirou Suzuki and Shun Shimohama},
  journal={Current drug targets},
  year={2012},
  volume={13 5},
  pages={
          623-30
        }
}
Parkinson's disease (PD) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. More than 50 epidemiological studies confirmed the low incidence of PD in smokers. Examining the distribution of subtypes of nicotinic acetylcholine receptors (nAChRs) in dopaminergic neurons of nigrostriatal system and its change in PD patients is quite important to elucidate possible neuroprotective cascade triggered by nicotine… CONTINUE READING
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