α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

@inproceedings{Pirttimaki20137NR,
  title={α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model},
  author={Tiina Maria Pirttimaki and Neela Krushna Codadu and Alia Awni and Pandey Pratik and David Andrew Nagel and Eric James Hill and Kelly Tennyson Dineley and H Rheinallt Parri},
  booktitle={PloS one},
  year={2013}
}
It is now recognized that astrocytes participate in synaptic communication through intimate interactions with neurons. A principal mechanism is through the release of gliotransmitters (GTs) such as ATP, D-serine and most notably, glutamate, in response to astrocytic calcium elevations. We and others have shown that amyloid-β (Aβ), the toxic trigger for Alzheimer's disease (AD), interacts with hippocampal α7 nicotinic acetylcholine receptors (nAChRs). Since α7nAChRs are highly permeable to… CONTINUE READING
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